Transformative therapies for diseases of cardiovascular aging

Vasa has  three active preclinical programs:

1. VS-041 is the first personalized medicine-based treatment of HFpEF.  VS-041 shows robust reduction of cardiac fibrosis in a preclinical HFpEF model and inhibits release of signaling collagen fragments, such as PRO-C6, that mediate fibroinflammatory responses and are biomarkers of worse outcomes in HFpEF patients. Phase 1 clinical trial of VS-041 is planned for Q2 2024.

2. Long acting apelin peptide analogs for combination treatment with incretins in obesity patients at risk for skeletal muscle loss or cardiovascular disease. As a monotherapy, long acting apelin agonists could also be beneficial in muscle atrophy, heart failure, chronic kidney disease, and peripheral artery disease.

3. A best-in-class inhibitor of CamKIId for heart failure and life-threatening arrhythmias.

Platform

At Vasa Therapeutics, the overall drug discovery process begins and ends with our cutting-edge computational chemistry and design platform. Our process integrates everything from the strategic identification of viable biological targets to the design and identification of small molecule or peptide therapeutics that are triaged through our drug discovery testing funnel, both in-house and with a network of strategic partnerships and international contract research organizations (CROs).